![]() A significant survival benefit was demonstrated for the nivolumab + ipilimumab arm versus chemotherapy alone however the numerical OS rates were lower and there has been a cross-over of the survival curves after 6 months of treatment indicating rapid progressing patients under nivolumab + ipilimumab treatment (OS = 13.2 vs 10.7 months HR = 0.64 99.5% CI = 0.46–0.90 p = 0.001). This group had a highly statistically significant improvement in OS with nivolumab + chemotherapy treatment versus chemotherapy alone, 15.4 vs. The coprimary endpoints were overall survival (OS) and progression-free survival (PFS) in patients with tumor cell PD-L1 expression (tumor proportion score, TPS) ≥ 1%. The CheckMate 648 study randomly assigned 970 patients with unresectable advanced, recurrent, or metastatic ESCC to the following arms : nivolumab 240 mg q2w+chemotherapy with fluorouracil (800 mg/m 2 daily, between days 1–5) and cisplatin (80 mg/m 2 at day 1) q4w nivolumab at 3 mg/kg q2w plus ipilimumab at 1 mg/kg q6w or chemotherapy alone (same schedule as first arm). This opened the door for various immunotherapy compounds in different settings of esophageal cancer. The first data of the Keynote-181 trial was presented in 2019, which changed, at least in the USA, the second-line treatment strategy of PD-L1-positive patients with esophageal squamous cell cancer (ESCC). This review summarizes the highlights regarding gastroesophageal tumors at the ASCO 2021 congress.įull size image Esophagus and gastroesophageal junction (GEJ) cancerĮsophageal cancer (EC) has been one of the diseases in oncology where hardly any treatment advances had been made until 2019. Not only immunotherapy trials, but also targeted therapy studies such as the FIGHT trial investigating the anti-FGFR2b monoclonal antibody bemarituzumab attracted huge interest, not only due to extension of survival in experimental group, but also due to the innovative design of this trial. ![]() However, this effect seems to be dependent to PD-L1 expression. ![]() ![]() The updates on the CheckMate 649 and CheckMate 577 trials again underlined the significant clinical contribution of nivolumab in advanced and localized gastroesophageal cancer, respectively. For advanced squamous cell carcinoma, immunotherapy and chemotherapy combinations revealed by the CheckMate 648 and ESCORT-1st trials have been implemented into the clinical practice. Many immunotherapeutic agents were shown to be beneficial for upper gastrointestinal tumors. The oncological community witnessed several practice-changing clinical reports in this years’ annual congress of the American Society of Clinical Oncology (ASCO). ![]()
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![]() ![]() "The price is affordable, and the applicator is designed specifically for under-eye circles," she noted. "This is my usual go-to," said one reviewer. "It's definitely not an everyday formula if you're just dabbing on some makeup and running out the door, but it's a must-have for full glam," she said.Ĭoverage Level: Full | Finish: Satin | Shades: 35 | Size: 0.3 ounces | Cruelty-Free: YesĪccording to our testers, there was much to love about this fan-favorite dark circle treatment concealer. However, she also added that it worked best for more glamorous looks because its formula is thicker and more full-coverage than others she tried. "Its non-drying formula lasted all day without creasing or creating extra wrinkles."Īnother tester noted that she loved this concealer for brightening her under-eyes, specifically. "The matte formula imparts smooth finish that isn't shiny," said one tester, who also noted that she used it for contouring, too. ![]() And when we say highest possible, we mean it-three editors tested this formula, and each of them gave it perfect scores for its texture, staying power, coverage, and creasing. Tarte's best-selling Shape Tape concealer has long been a Team Byrdie fave, so it's no surprise it earned the highest possible 5/5 marks from our testers across the board. ![]() ![]() ![]() There are many individual entertaining scenes, most of which are the film's lighter moments. who also steals scenes as Cooper's FBI superior. There are also a few nicely done smaller parts, including Louis C.K. Don't be surprised if you see any of these names come Oscar time. While Lawrence is a scene-stealer as Rosalyn, the clueless housewife. Cooper continues his transformation from pretty boy to genuine actor. Adams plays her most adult role, flirting with nudity in several scenes. A character who manages to get by on his confidence. Bale continues to prove that he's a chameleon, burying himself inside the slovenly, out-of-shape Irving. There's even a little bit of meta-humor related to the time-period when a microwave oven is introduced to the Rosenfelds who cluelessly call it a "science oven". Adams and Lawrence come off a little better than the men, but their hair and clothes are equally dated. Cooper's Richie, meanwhile, has an unflattering permanent, which requires wearing curlers. ![]() The film opens with Bale's Irving assembling his combover with great care, using a hairpiece and glue and it becomes something of a running joke throughout the film. The costumes, the cars and especially the hair all just scream 1970s in all of its excesses. It's obvious from the beginning that the cast and production team had a lot of fun with the time period. Cooper plays Richie DeMaso, the arrogant upstart FBI agent running the operation, even though clearly he's in over his head. Christian Bale plays Irving Rosenfeld, a con-man from Long Island with a young rather ditzy wife, Rosalyn (Lawrence), and a fellow con-artist mistress, Sydney (Adams), who is trapped into working with the FBI to set-up a sting operation in the hopes of nabbing everyone from mobsters to politicians. The film deals with the ABSCAM operation of the 1970s and early 1980s, although the subtitle before the film only cheekily says, "Some of this actually happened.". He brings with him the two stars of that film, Jennifer Lawrence and Bradley Cooper. Russell, hot off of last year's Silver Linings Playbook. The film is directed and co-written by David O. There are winners and losers by the film's end, but basically, who cares which is which? ![]() Nearly every character is unlikable and there's basically zero emotional investment in anything that happens. Everything about it is of the highest quality in terms of production value and performances. Some movies are easy to admire, even if they're not so easy to love. Bradley Cooper and Christian Bale in American Hustle. ![]() ![]() ![]() From a brief over of what RAW images are (and how they differ. Id agree with others in using Darktable or Rawtherapee as Gimp plugins. Users can change images in almost all the same ways that plugins can. In this GIMP tutorial featuring Darktable, I show you how to edit a RAW photo from start to finish using these two free programs. ![]() Plugins for GIMP are outside programmes that run under the control of the main GIMP programme and work closely with it. Plugins are one of the best things about GIMP because they make it easy to add new features. Filter presets are like tool presets in that they let you save your favourite settings and use them again when you need to. But, I’ve never used the plugin, wouldn’t know how it would work, what I would need to do to check. It’s output XCF file when running in plugin mode and will not contain the original Exif-metadata, So I manual export PNG file use Darktable then open it in GIMP. Hi, welcome If I start gimp -verbose from a terminal window, I see Initializing plug-in: '/usr/lib64/gimp/2.0/plug-ins/file-darktable/file-darktable' and no errors. There are a few options that are the same for all of these filters, but some of them only show up in certain situations. In particular the RAW format is first processed by the Darktable-plugin then to the GIMP. GIMP uses GEGL, which is a library for processing images. Also, demosaicing apps can usually apply a 'recipe' in batch mode on several files. You can run the demosaicing in a separate app before calling Gimp on the demosaiced files (TIFF or else). Most filters in GIMP 2.10 are GEGL filters. The whole purpose of these plugins is to let the user do specific processing before passing the picture to Gimp. Images will not be returned to darktable in this mode, but additional images can be sent to GIMP without stopping it. Check the rundetached button to run GIMP in detached mode. All tool options dialogues have four buttons at the bottom that let you save, restore, delete, or reset presets. in the export dialog select Edit with GIMP and select the format and bit depth for the exported image. You can give each preset a name to make it easier to find the one you want. Presets are saved settings for a tool that are easy to get back when you need them. This plugin helps to smooth out the curves and get rid of the clutter that comes from having too many nodes. If your path has too many nodes, the curves can look bumpy. These are the top plugins that Ive come ac. This is because, by default, GIMP adds a lot of nodes along your path. In this video, I go over my 9 favorite plugins that I think every GIMP user should have in their toolkit in 2022. This is useful when converting selections or text to a path, for example. With this free, easy-to-install plugin, you can reduce the total number of nodes on a path to make it easier to follow. => ERREUR : Une erreur s’est produite dans build().The “Simplify” plugin, which we just discovered, is another one of my favourites. Make: *** Attente des tâches non terminées. Make : on quitte le répertoire « /home/jacotux/tmpdir/darktable-git/src/darktable/build » home/jacotux/tmpdir/darktable-git/src/darktable/src/imageio/format/jxl.c:196:3: erreur: nom de type « bool » inconnuĬompilation terminée en raison de -Wfatal-errors. home/jacotux/tmpdir/darktable-git/src/darktable/src/imageio/format/jxl.c: Dans la fonction « write_image »: Building C object lib/darktable/plugins/imageio/format/CMakeFiles/jxl_format.dir/jxl.c.o It's been two days that my compilations are crashing, with 4% of the target, it's annoying. ![]() ![]() Terms, conditions, pricing, special features, and service and support options subject to change without notice.The Connector uploads all customer information and job details directly to your smartphone or tablet, making it easy to submit time sheets to QuickBooks online when you're on the road. ![]() QuickBooks Time mobile access is included with your QuickBooks Time subscription. Not all features are available on the mobile apps and mobile browser. Devices sold separately data plan required. The QuickBooks Time mobile app works with iPhone, iPad, and Android phones and tablets. System Requirement: QuickBooks Time requires a computer or a device with a supported Internet browser and an Internet connection (a high-speed connection is recommended). Phone Support: For hours of support and how to contact support, click here. Terms, conditions, pricing, special features, and service and support options subject to change without notice. To cancel your subscription at any time go to “Account & Billing” in QuickBooks Time and select the “Close Account” tab then “Permanently Close My Account.” You will not receive a prorated refund. This offer can’t be combined with any other QuickBooks Time offers. To be eligible for this offer you must be a new QuickBooks Time customer and sign up for the monthly plan using the “Try it free for 30 days” option. Sales tax may be applied where applicable. If you add or remove services, your service fees will be adjusted accordingly. Each worker is an additional $/month depending on your selection of QuickBooks Time Premium or Elite. To continue using QuickBooks Time after your 30-day trial, you’ll be asked to present a valid credit card for authorization, and you’ll be charged on a monthly basis at the then-current fee for the service(s) you’ve selected until you cancel. *Offer terms 30-day free trial First thirty (30) days of subscription to QuickBooks Time, starting from the date of enrollment is free. To avoid any trouble (and paying out too much on payroll), consider these important questions. Here are three of the most common laws being broken, though there are many to be aware of. Government compliance checklistīefore using any timesheet, we highly recommend checking to ensure you and your employees are adhering to government compliance guidelines. Managers can then calculate the employee’s total time for payroll. Step 4: When it’s time to hand the timesheet in, employees sign the top of the form. Step 3: Employees can fill in the day, date, job/shift, job/shift code, their time in/out (including breaks), and any remaining hours (overtime, sick, holiday, and vacation). Step 2: Fill in your employee’s name, their manager, your company’s name, the pay period start date, your employee’s standard pay rate, and your employee’s overtime pay rate. Word and PDF files are read-only, so print a paper copy for best results. Hours, rates, and sub-total formulas will calculate automatically. ![]() If you’re using the Google Sheet online, “Total (Hours)” will need to be added manually based on clock in/out times. Make a copy of the Google Sheet to fill in values on your computer. Please note, values on XLS files can be filled in on your computer. Step 1: Download the bi-weekly timesheet template of your choice. Use QuickBooks Time accurate time tracking to grow your business and better manage employees. ![]() ![]() Want to do away with manually tracking and entering time for payroll? QuickBooks Time is an online time tracking solution, available free for two weeks. Use our bi-weekly timesheet template for employee hours, overtime, vacation days, and even lunch breaks. The template is printable and optimized for Excel. The bi-weekly timesheet template is a semimonthly, or two-week, timesheet for tracking employee time. How to use the bi-weekly timesheet template ![]() ![]() ![]() In 2013, the New York Television Festival and FOX Broadcasting Company teamed up to host the 6th annual FOX-NYTVF Comedy Script Contest. "Wreck Hunters" by Gary Simson and Andrew Giacometti - Los Angeles, CA."Sap Wars" by Hilary Weisman Graham and George Cilley - Francestown, NH."Hackers" by Sean Skelton and Manny Kivowitz - New York, NY."Crash Junkies" by Steve Garrett and Jeff Steinborn - Nashville, TN."Cleveland Art" by Jeannine Denholm, Dave Denholm, and Stefan Wallach - Cleveland, OH.Winner: "Wreck Hunters" by Gary Simson and Andrew Giacometti - Los Angeles, CA From there, the creators of one winning project will receive $10,000 as well as the opportunity to participate in the creation of a network pilot based on their concept. Finalists will also receive $1,500 to shoot additional tape to further enhance their projects. Each of the five will receive notes on their projects from NYTVF and HISTORY development executives as well as a prize of $2,500. HISTORY and the NYTVF are pleased to announce the five finalists chosen from the field of 15 semi-finalists in the second annual HISTORY Unscripted Development Pipeline. "Sushi Dojo" by Scott Mason, Sebastian Lucrecio, and David Bouhdana (New York, NY)."Get Me Out of Here" by Dan O'Conner (Allendale, NJ)."The Foxhole" by Rick Walters (Seattle, WA)."Chuck and Cory's Tandemonium" by Joanna Shaw and Elena Sorre (New York, NY and Los Angeles, CA)."Barn Raiser" by Steve Zink (Ringoes, NJ).Winner: Elena Sorre for her project “Green Rush: Alaska” (New York, NY) One winner, selected by HISTORY, was awarded the opportunity to produce a pilot presentation with a minimum $25,000 budget in conjunction with NYTVF Productions. HISTORY development executives selected five finalists, each of whom received notes on their projects, a $2,500 prize, and an additional $1,500 to shoot a short presentation further exploring their subject. History and the NYTVF teamed up again for an innovative program seeking original unscripted television tape and treatments from independent artists and production companies. Click on the years below to explore some of NYTVF's past endeavors. Since 2005, the NYTVF has been offering independent creators opportunities to submit their projects. Visit the NYTVF Artist Benefits page for more information, and check out the Top 10 Reasons to Submit to the NYTVF on the NYTVF Blog. ![]() Official Artists receive free accreditation for the annual Festival (held in Manhattan) where they will enjoy exclusive access to NYTVF Connect. If a project you create is named an Official Selection, you are invited to participate in the Festival as an Official Artist. The Resources Page gives you access to NYTVF partners offering free and reduced-priced access to their libraries of production and post-production materials. The NYTVF wants you to create the best content you can, with as many resources at your fingertips as possible. The winning project will enter into an option deal with the network/studio/partner.įor general questions about the Festival, please visit our FAQ page. Projects selected as finalists or semi-finalists in sponsored initiatives will also be named as Official Selections in the New York Television Festival and are eligible for the benefits of NYTVF Connect. These sponsored initiatives allow creators to tailor their original projects exclusively with a particular partner in mind. The NYTVF often collaborates with networks and studios to provide exclusive submission opportunities for indie creators to get into business with specific industry partners. NYTVF Scripts accepts submissions of pilot scripts and offers a Festival experience designed to provide maximum exposure, access, and opportunity to projects that are chosen as NYTVF Scripts Official Selections.įor more information, visit the main NYTVF Scripts Page. IPC Official Selections are eligible for the competition's category and individual achievement awards as well as guaranteed development deals from Festival Development Partners and the opportunity to submit to NYTVF Pitch.įor more information, visit the main IPC Page. Official Selections from the IPC screen in competition during the New York Television Festival. The Independent Pilot Competition (IPC) is the NYTVF’s flagship competition, accepting independently-produced, original television pilots and web series from around the globe. For updates and announcements about upcoming initiatives, follow the NYTVF on Twitter, Facebook, and Instagram.īack to top THE INDEPENDENT PILOT COMPETITION There are currently no open submission opportunities. ![]() ![]() → Car rental: Discover Cars is great at finding and comparing the best car rental deals. → VPN: Boost your privacy and internet security with NordVPN. → eSIM: Knowroaming and Airalo both have affordable USA data plans. 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These Maine travel resources will make your trip planning a breeze: Joey_C’s Twitter Feed Tweets by Joey_C GMG Local Music ScheduleĬlick For Common GMG Topics 2011 Art Art Haven Beautiful Industry Block Party Cape Ann Cape Ann Animal Aid Cape Ann Museum Captain Joe and Sons Charadrius melodus Chickity check it! chris mccarthy Dancing David B. Sprite6308 on I think this is Ernestina goin…Īnonymous on Having a ball! GHS Fishermen B… Sprite6308 on Saturday, another glorious Sat…ĭonna Ardizzoni on Schooner Fest Friday Greet The…ĭonna Ardizzoni on I think this is Ernestina goin… Sabine Cray on The amazing Gloucester Schoone…ĭonna Ardizzoni on Saturday, another glorious Sat… MAJack on Happy Birthday To GloucesterCa…ĭonna Ardizzoni on The amazing Gloucester Schoone… GMG Wins CBS Boston Most Valuable Blogger GMG Wins CBS Boston Most Valuable Blogger 2013 North Shore Magazine Readers Choice- Best Blog GMG- 2012 North Shore Magazine Readers’ Choice & Editors’ Choice Award Winners Click For Your Cape Ann License Plate Recent Comments RSS - Comments Good Morning Gloucester Facebook Personal Schooner Festival - pat morss.The amazing Gloucester Schooner Festival. ![]() Want To Look At This Waterfront Property With Dock Space and 4 Units? Contact My Beautiful Wife Katelyn 97.An error has occurred the feed is probably down.Cox David Cox dogs Donna Ardizzoni Downtown Gloucester Eastern Point Eats entertainment Family Fredrik Bodin gloucester Gloucester at Dawn GloucesterCast Gloucester Harbor Gloucester Ma Gloucester Smiles GMG Good eggs Good Harbor Beach Good Morning Gloucester GoodMorningGloucester Greasy Pole Joey Ciaramitaro Kim Smith live music lobster Local Magnolia Magnolia Pier Main Street night life Niles Pond Passports PAT AND JIM DALPIAZ Paul Frontiero People Photography Podcast Rockport Rocky Neck Rubber Duck Saint Peter's Fiesta Sawyer Free Library Schooner Seagull Sharon Lowe Shore Road Sista Felicia Sista Felicia Eats Slide Show Smiles Stacy Boulevard Stage Fort Park St Peter's Fiesta sunset The Bean The GloucesterCast Podcast The Rhumb Line Things to do Video visitors What Up Homie? GMG Wins CBS Boston Most Valuable Blogger GMG Wins CBS Boston Most Valuable Blogger 2013 North Shore Magazine Readers Choice- Best Blog GMG- 2012 North Shore Magazine Readers’ Choice & Editors’ Choice Award Winners Joey_C’s Twitter Feed Tweets by Joey_C GMG Local Music Schedule Send the self addressed and stamped envelope to the dock at 95 East Main St Gloucester Ma 01930 care of Joey (put my name in big letters to make sure it gets to me)Ĭlick For Common GMG Topics 2011 Art Art Haven Beautiful Industry Block Party Cape Ann Cape Ann Animal Aid Cape Ann Museum Captain Joe and Sons Charadrius melodus Chickity check it! chris mccarthy Dancing David B. As long as supplies last if any GMG folks want a bumper sticker but can't drop down the dock, just send a self addressed and stamped envelope longer then 7 and a half inches and I'll drop one in the mail for you. ![]() ![]() ![]() Whew! What a list! Hopefully, you have a better idea of what tax deductions you can take as an Etsy seller! The IRS says you can take a tax deduction for expenses that are reasonable and necessary. Heavy duty tape and dispenser for packaging boxes Fees and expenses to register your trademarkĩ9. Payments to affiliates of your productsĩ8. The monthly fee for Etsy Plus or Etsy Premiumĩ7. ![]() Payroll processing if you are an S Corp.ĩ4. TaxJar) extremely helpful with all the sales tax changesĩ3. Social Media manager virtual assistantĨ8. Education or training for virtual assistantsħ6. At the end of your offer term, your subscription will be automatically billed at the standard subscription rate, currently at US29.99 /mo (plus applicable taxes), unless you elect to. Microphone for business projects ( this is the one I use, good but cheap)ħ1. Eligible students 13 and older and teachers can purchase an annual membership to Adobe Creative Cloud for a reduced price of US19.99 /mo for the first year. Interest on a business credit card or business loanĦ9. Donations to charity (deducted on your personal taxes, but money can come from business accounts)Ħ5. Miles, you drove in your personal car that was for a business purposeĦ0. Home office tax deduction (where you make your products or store your inventory)ĥ9. Monthly fee to have your own online shop (ex. Photo editing software for Etsy imagesĥ4. Materials for new product experimentationĥ3. Ingredients for food for a specialty food Esty shopĥ1. Appointment and client meetings scheduling tool (ex. Google apps subscription to get a custom emailĤ6. Half sticker sheets for printing postage labelsĤ5. Blank note cards to include a handwritten thank you note in each packageĤ1. Book to help you understand how to file your Etsy business taxesĤ0. Postal scale to weigh your packages prior to shipmentģ8. Picmonkey to design your own pins and printablesģ2. Cost of wholesale supplies purchased in bulk for resaleģ1. Price paid for vintage items at garage and estate sales (keep a log!)ģ0. The yearly cost of domain name purchase and registration (ex. Online program for filing your taxes at year-endĢ6. Course to teach you how to do your own Etsy shop bookkeepingĢ5. Online accounting program monthly fee (my recommendation- QuickBooks)Ģ2. The portion of camera purchase related to your business (good product photographs are so important!)Ģ1. The portion of computer purchase expense related to your businessĢ0. The portion of internet expense related to your businessġ9. The portion of cell phone expense related to your businessġ8. 50% of the cost of meals at a conferenceġ7. Travel costs to a conference or craft showġ4. Coaching fees to help you grow your businessġ3. Online courses to help you grow your businessġ2. Printer paper and ink (use Quillfor good prices and coupons!)ġ0. Virtual assistant for general help ( my VA is great!)ĩ. Adobe creative cloud for tools such as PhotoshopĦ. Email service provider subscription fee (ex. This post is meant for general informational purposes only, and should not be taken as legal, tax, or accounting advice.Ģ. This post contains affiliate links, see my disclosure here. Whether you sell handmade products, craft supplies, or vintage lovelies, we have got you covered! Here are 101 tax deductions to get you started! There are at least 101 tax deductions for Etsy sellers! Don’t miss out on a single tax deduction for your Etsy shop business. ![]() ![]() ![]() This lets the user check the results of any sort of change he applies to his pictures. With a clean interface, Ashampoo Photo Optimizer consists of three panels that show the contents of the concerned folder, the folder structure, and the recent picture used. Download this optimizer and explore the best of its features now. ![]() If you are looking for an adequate optimizer too, Ashampoo Photo Optimizer is a great choice. this update led to a significant improvement in the reviews of this software. for the users of Windows 7 / Windows 7 64 / Windows 8 / Windows 8 64 / Windows 10 / Windows 10 64. The latest version of Ashampoo Photo Optimizer was introduced on by the developers i.e. These features include contrast and color adjustments, a red-eye corrector, and some special filters. Description about Ashampoo Photo Optimizer FreeĪshampoo Photo Optimizer is a handy photo managing program that carries almost all the standard tools that you need for image optimization. This type of license is used for software or games that are intended for sale or commercial use. Along with time limitations, sometimes trial programs may also limit the features. Trial programs give the user a chance to use it for a particular time, generally 15-90 days, to check whether the software fits his/her requirements or not. However, in some cases, all features become unavailable if you do not get the program license. Demos are available for an unlimited period. If the user wants advanced features or an ad-free experience, then he/she needs to pay for it. Demoĭemo software offers limited features for free. However, if the user wants additional features, then he/she can pay for them. Free-to-play games can be downloaded and played without any charges. It is a license type used specifically for video games. Such software is free for both personal and commercial use. Open Source programs allow the user to check, change, or improve the software’s code. Such programs can be used freely in both personal and commercial environments for unlimited time. FreewareĪs it is evident from the name, freeware is software that is available for download without any charges whatsoever. Below are the commonly used license types. Every software has a unique license type that you can find on the program page, search, or the webpage of category. ![]() ![]() ![]() You need to correctly enter the anti-spam text. Part of VIntouch Ad Astra collection, these earrings feature delicate faceted pink quartz - youll love their neutral shade which makes them perfect to be. We will endeavour to respond as soon as possible. Sterling Silver Rhodium Plated Diamond And Pink Quartz Earrings Drop & Dangle Material: Sterling Silver Purity: 925 Length of Item: 40 mm Width of Item: 10. Square pink sterling silver stud earrings E265P5 $39.00 Questions? 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